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    The Peter Attia Drive

    The Peter Attia Drive

    Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

    The Peter Attia Drive

    Mon Jul 22 2024

    The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy | Ted Schaeffer, M.D., Ph.D.

    testosteroneprostate cancer

    The podcast episode focuses on the topic of testosterone and prostate cancer, specifically discussing the TRAVERSE trial. The TRAVERSE study looked at men who were hypogonadal and aimed to replete their testosterone levels to a eugonadal level. The study found that supplementation of endogenous testosterone with exogenous testosterone did not increase the risk of being diagnosed with prostate cancer. Men with low PSA levels have a low risk of being diagnosed with prostate cancer, and changes in PSA levels can be used to monitor for potential risks when supplementing with exogenous testosterone.

    The Peter Attia Drive

    Mon Jul 15 2024

    AI in medicine: its potential to revolutionize disease prediction, diagnosis, and outcomes, causes for concern in medicine and beyond, and more | Isaac Kohane, M.D., Ph.D.

    AI in MedicineNeural NetworksMedical DiagnosticsHealthcarePersonal Data

    The podcast explores the evolution of AI in medicine, advancements in neural networks and GPUs, AI in medical diagnostics and healthcare, speculations on AI entities and personal data. Key insights include the impact of AI on radiology, the potential of AI in predicting neurodegenerative diseases, and concerns about relying too heavily on AI in medicine. The episode also delves into the blurring line between human creativity and AI-generated content.

    The Peter Attia Drive

    Mon Jul 08 2024

    Zone 2 training: impact on longevity and mitochondrial function, how to dose frequency and duration, and more | Iñigo San-Millán, Ph.D.

    longevityexercisecyclingmetabolismmitochondria

    This episode explores the science of longevity through a deep dive into Zone 2 exercise with Tour de France champion Teddy Pogacar. Topics covered include lactate and fat oxidation, cycling physiology, training strategies, and the impact of exercise on metabolic health. The episode also discusses the role of lactate in cancer metabolism, the effects of COVID-19 on mitochondrial function, and the potential benefits of geroprotective agents. Overall, it provides valuable insights into optimizing performance, improving metabolic efficiency, and promoting longevity through exercise.

    The Peter Attia Drive

    Mon Jul 01 2024

    AMA #61: Sun exposure, sunscreen, and skin health: relationship between sun exposure and skin cancer, vitamin D production, and photoaging, how to choose a sunscreen, and more

    LongevityPremium MembershipSkin CancerSun ExposureSunscreen

    The episode of the DRIVE podcast discusses the science of longevity, premium membership benefits, skin cancer, sun exposure, and sunscreen. It provides insights into the impact of UV radiation on vitamin D conversion, photo-aging, and different skin types' implications on sun exposure. The episode also covers the importance of sunscreen and its impact on UV radiation and skin cancer.

    The Peter Attia Drive

    Mon Jun 24 2024

    Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.

    exerciseagingfitnessstrength trainingfall prevention

    The podcast episode provides practical advice on starting exercise for individuals aged 50 and above. It emphasizes the importance of exercise for longevity and highlights specific age milestones where considerations for strength, vestibular changes, and fall risks become critical. The episode covers topics such as the four pillars of aging, population-based reductions in activity, determining exercise intensity, the importance of VO2 Max for longevity, effective training strategies, fall risk and injury prevention, preventing falls and fractures, bone health and strength training, and optimizing protein intake and exercise.

    The Peter Attia Drive

    Mon Jun 17 2024

    AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

    Ask Me AnythingCognitive DeclineMetabolic HealthSleep

    This episode is a sneak peek of the Ask Me Anything (AMA) episode of the Drive podcast. The AMA covers a wide range of topics including the prevention of cognitive decline, the relationship between cardiovascular disease and Alzheimer's disease, and nutrition. Other topics discussed are blood pressure, step requirements per day, and standing versus sitting desks.

    The Peter Attia Drive

    Mon Jun 10 2024

    Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson

    Heart Rate VariabilityHRV MeasurementAutonomic Nervous SystemTrainingLongevity

    The podcast explores the science of longevity and the role of heart rate variability (HRV) in training and overall health. It covers topics such as the history and evolution of HRV measurement, different tools for measuring HRV, optimal locations for HRV measurement, the autonomic nervous system's role in HRV, the impact of lifestyle choices on HRV, using data-driven insights for training, monitoring heart rate recovery and conditioning, balancing anaerobic and aerobic training, HRV and medication effects, and the importance of monitoring HRV for overall health. The episode provides practical tips and recommendations for HRV monitoring and training.

    The Peter Attia Drive

    Mon Jun 03 2024

    NEW: Introducing quarterly podcast summaries - Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more

    interviewskey insightsmuscle protein synthesisanabolic resistancepremium membership

    This episode covers a range of topics including preparing for interviews, key insights from past episodes, factors influencing muscle protein synthesis, anabolic resistance, and premium membership benefits. The importance of staying active to prevent muscle loss is emphasized. Listeners are encouraged to provide feedback on the new AMA episode format. Contact information and subscription details are provided.

    The Peter Attia Drive

    Mon May 27 2024

    A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

    ClothoLongevityBrain HealthCognitive EnhancementAlzheimer's Disease

    The episode explores the science behind Clotho, a protein or gene associated with longevity and brain health. The discussion covers its role in regulating cognitive functions, brain health, and potential treatment for neurodegenerative diseases like Alzheimer's. Key insights include the effects of aging on Clotho levels, the relationship between Clotho and platelets, and the potential use of Clotho as a treatment for Parkinson's disease and Lewy body dementia. The episode also delves into the KLVS gene variant and its association with cognitive enhancement and reduced Alzheimer's risk. Additionally, it discusses Clotho as a potential diagnostic biomarker for chronic kidney disease and its broader implications for cancer, cardiovascular disease, and kidney disease. The episode concludes with the challenges of Alzheimer's research and the importance of philanthropy in funding innovative science projects.

    The Peter Attia Drive

    Mon May 20 2024

    Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage MAFLD and liver disease | Julia Wattacheril, M.D., M.P.H.

    Liver PhysiologyLiver DiseaseLiver TransplantsAlcohol and Liver HealthMetabolic-Associated Liver Disease

    This episode explores the science of liver physiology, liver diseases, and the impact of lifestyle on liver health. Topics covered include liver transplants, alcohol's impact on the liver, metabolic-associated liver disease, fructose metabolism, and future treatments for liver disease. The episode emphasizes the importance of proactive liver health monitoring and lifestyle interventions for improving metabolic health.

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