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    The Kevin Rose Show

    Carolina Reis Oliveira & Alessandra Zonari | OneSkin: Aging Myths, Senescent Cells, and How to Age Slower (#56)

    Tue May 07 2024
    skin healthskincareagingcollagenpeptidesfastingred light therapy

    Description

    This episode explores the impact of lifestyle choices on skin health, the role of fasting in promoting healthy skin, and the importance of collagen and skincare ingredients. It also delves into the scientific research behind One Skin's innovative approach to reversing skin aging and the effectiveness of their products. Additionally, the episode discusses skincare procedures, red light therapy, and common misconceptions in skincare practices.

    Insights

    Men's Growing Interest in Skincare

    There is a growing trend of men becoming interested in skincare due to increased awareness about well-being and longevity.

    Preventing 'Zombie Cells' for Healthy Skin

    Efforts are being made to prevent the build-up of 'zombie cells' through specific targeting or inhibiting their inflammatory factors.

    The Role of Sugar in Skin Inflammation

    Sugar can bind to skin proteins and damage collagen, leading to skin inflammation.

    Importance of Hydration for Skin Health

    Hydration and adequate water consumption are essential for healthy skin and overall body function.

    Different Types of Collagen and Their Functions

    Different types of collagen have specific roles in the body, with collagen type 1 and 3 being main components of the skin, while collagen type 2 is more related to cartilage.

    Vitamin C's Role in Skincare

    Vitamin C is an antioxidant that can help with skin health, collagen production, and suppressing melanin production.

    One Skin's Approach to Skin Aging

    The company is focused on developing products that target the root cause of skin aging by reducing senescent cells.

    Scientific Evidence of One Skin's Products

    A compound called OS one showed positive effects on reducing fine lines and dark spots, outperforming retinol and cajic acid in melanin production.

    Enhancing Skincare Procedures with Skin Health

    Products that promote skin health can enhance the results of skincare procedures.

    Red Light Therapy for Skin Health

    Red light therapy has been shown to improve skin health by enhancing cellular function and collagen production.

    Chapters

    1. Skin Health and Lifestyle Choices
    2. Understanding Aging and Skin Health
    3. Fasting and Epigenetic Changes
    4. Impact of Sugar and Collagen on Skin Health
    5. Different Types of Collagen and Skincare Ingredients
    6. Vitamin C and Skincare Products
    7. One Skin's Approach to Skin Aging
    8. Scientific Evidence and Results of One Skin's Products
    9. Enhancing Skincare Procedures and Skin Health
    10. Red Light Therapy and Skincare Techniques
    11. Research on Peptides and Skincare Misconceptions
    12. Conclusion and Additional Resources
    Summary
    Transcript

    Skin Health and Lifestyle Choices

    00:00 - 06:41

    • Skin health is influenced by lifestyle choices and can be impacted by factors like sugar consumption and accumulation of senescent cells.
    • Data breaches can lead to personal information being leaked and sold by data brokers, but services like Delete Me can help remove this data from the web.
    • Cold plunges from Plunge.com are endorsed for their impact on mood and energy levels, with customizable options available for different preferences.
    • The podcast focuses on skin health, featuring experts from One Skin who are PhDs in the field and have been recognized by other respected professionals.

    Understanding Aging and Skin Health

    06:12 - 13:28

    • Dr. Sinclair and Dr. Aranda Patrick discussed peptides researched by four female founders with expertise in skin regeneration, stem cell biology, immunology, and bioinformatics.
    • There is a growing trend of men becoming interested in skincare due to increased awareness about well-being and longevity.
    • Men are more willing to invest in science-backed skincare products that can prove their effectiveness.
    • The accumulation of damage over time leads to aging, affecting collagen production and causing inflammation from 'zombie cells'.
    • Efforts are being made to prevent the build-up of 'zombie cells' through specific targeting or inhibiting their inflammatory factors.
    • Prolonged fasting is suggested as a method to clear senescent cells and promote healthy skin.

    Fasting and Epigenetic Changes

    13:05 - 20:12

    • Dr. Volter Longo's research focuses on using fasting to clear dysfunctional senescent cells by depriving them of nutrients.
    • Fasting helps with autophagy, recycling dysfunctional cells and proteins to make way for new skin cells.
    • Epigenetic changes, like DNA methylation, can lead to different gene expressions in skin cells around 30 years old, affecting aging processes.
    • Sun exposure is the primary cause of skin aging, accounting for 90% of damage, which accumulates over time and impacts skin repair ability as one ages.
    • Targeting underlying mechanisms of aging through lifestyle choices can improve skin appearance but reversing signs of aging takes time and prevention is easier than reversal.

    Impact of Sugar and Collagen on Skin Health

    19:50 - 26:42

    • Sugar can bind to skin proteins and damage collagen, leading to skin inflammation.
    • Consuming a balanced diet with limited processed sugar is crucial for skin health.
    • High sugar intake can lead to spikes in glucose levels, potentially harming the skin.
    • Hydration and adequate water consumption are essential for healthy skin and overall body function.
    • Factors like sleep, stress, and alcohol consumption can impact skin health and inflammation levels.
    • Collagen supplementation plays a vital role in providing structural support to the skin and other organs.

    Different Types of Collagen and Skincare Ingredients

    26:23 - 32:47

    • Different types of collagen have specific roles in the body, with collagen type 1 and 3 being main components of the skin, while collagen type 2 is more related to cartilage.
    • Ingested collagen gets cleaved into peptides in the stomach and distributed throughout the body, not solely targeting the skin.
    • The amount of collagen intake varies among individuals based on their dietary protein needs and sources.
    • Retinol, a derivative of vitamin A, works by inducing cell renewal in the skin layers to address issues like pigmentation.
    • Addressing underlying issues like inflammation is crucial for long-term results in skincare treatments.

    Vitamin C and Skincare Products

    32:19 - 39:33

    • Vitamin C is an antioxidant that can help with skin health, collagen production, and suppressing melanin production.
    • The stability of vitamin C in skincare products is crucial, as it can easily oxidize if not formulated correctly.
    • Testing the antioxidant power of skincare products involves exposing them to free radicals and measuring their scavenging ability.
    • Maintaining hydration through water intake is essential for good skin quality, along with a healthy diet rich in vitamins like D, E, and omega-3 fatty acids.
    • Peptides are an important component in skincare products, and the company One Skin focuses on innovative skincare solutions backed by scientific research.

    One Skin's Approach to Skin Aging

    39:09 - 46:08

    • The company is focused on developing products that target the root cause of skin aging by reducing senescent cells.
    • They have created a novel proprietary peptide called OS1, which has been shown to reverse skin aging in laboratory tests.
    • The company went through a rigorous scientific process including lab experiments, peer-reviewed studies, and clinical trials to validate their product's effectiveness.
    • Their approach involves targeting senescent cells to reverse skin aging, backed by quantifiable measures of biological age.

    Scientific Evidence and Results of One Skin's Products

    45:48 - 52:48

    • In a study, skin barrier properties improved on the side containing a peptide compared to the other side.
    • Objective methods like expert blind analysis and software analysis are used to measure changes in wrinkles more accurately than subjective assessments.
    • Biopsies were taken from the outer arm to evaluate changes in skin age after using a product.
    • A compound called OS one showed positive effects on reducing fine lines and dark spots, outperforming retinol and cajic acid in melanin production.
    • For hyperpigmentation, combining exfoliation with products high in vitamin C and sunscreen is recommended over harsh treatments like hydroquinone or intense lasers.

    Enhancing Skincare Procedures and Skin Health

    52:43 - 59:26

    • Skin health is crucial for the effectiveness of treatments like laser procedures
    • Products that promote skin health can enhance the results of skincare procedures
    • Eye cream specifically formulated for delicate areas like under eyes can be more effective in reducing signs of aging
    • Maintaining a balanced skin microbiome is important for skin health and barrier function
    • Red light therapy has studies supporting its benefits for improving skin health

    Red Light Therapy and Skincare Techniques

    59:01 - 1:06:15

    • Red light therapy has been shown to improve skin health by enhancing cellular function and collagen production.
    • Consistent daily use of red light therapy is recommended for long-term results.
    • Micro needling can help induce repair pathways for acne scars, but effectiveness depends on the severity of the scar.
    • Using stem cells from PRP in conjunction with micro needling can aid in skin regeneration.
    • Peptides in skincare products can penetrate the skin effectively, leading to better results.
    • Massaging skincare compounds into the skin may not enhance their effectiveness but can promote blood circulation and skin health.

    Research on Peptides and Skincare Misconceptions

    1:05:50 - 1:13:11

    • Researchers are conducting molecular studies on skin tissue treated with peptides to analyze the effects on different types of skin cells.
    • The peptide being studied targets the underlying mechanism of aging and can work universally on all skin types and genders.
    • Efforts are focused on creating a universal formula for delivering the peptide to suit different skin types.
    • Common skincare misconceptions include the belief that a complex skincare routine with many products is necessary, and that causing excessive damage to the skin for a flawless appearance may not be beneficial in the long term.
    • Overuse of strong treatments like retinol or Botox can potentially harm the skin by exhausting it, emphasizing the importance of finding a balance in skincare practices.

    Conclusion and Additional Resources

    1:12:57 - 1:13:11

    • Two places inside the website are good sources for information on overall health and longevity.
    • The host thanks the guest for joining them on the show.
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